Hakham Muhammad Issa Al-Issa was a senior Hamas military leader and a co-founder of the Izz ad-Din al-Qassam Brigades, the military wing of Hamas. He played a key role in the development of Hamas' military infrastructure and training, leading the training headquarters and serving on the group's General Security Council. Al-Issa was instrumental in building Hamas' force capabilities in the Gaza Strip. On June 28, 2025, the Israeli military confirmed that Al-Issa was killed in an Israeli airstrike targeting the al-Sabra neighborhood of Gaza City. This strike was part of ongoing Israeli operations against Hamas amid the intensified conflict in the region following the October 7, 2023 attacks. His death was publicly acknowledged by the Israel Defense Forces, which identified him as a senior figure responsible for planning and training within Hamas' military wing. His assassination reflects Israel's targeted efforts against Hamas leadership during the Gaza conflict[3][5][6]. It is important to distinguish Hakham Muhammad Issa Al-Issa from other individuals with similar names, such as Dr. Mohammad bin Abdulkarim Al-Issa, a Saudi Arabian Islamic scholar and former Minister of Justice, or Mohammad Issa, a late Hezbollah commander killed in 2015. Hakham Muhammad Issa Al-Issa's prominence relates specifically to his military role within Hamas and recent events in Gaza[1][2][3]. No further detailed biographical information about Hakham Muhammad Issa Al-Issa’s personal background or early life is publicly available in the provided sources. His current relevance is tied directly to his leadership role in Hamas and his recent assassination during the ongoing Israeli-Hamas conflict.